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They get under your skin : Strongyloides stercoralis and hookworm distribution, risk profiling, and control in Cambodia

Forrer, Armelle. They get under your skin : Strongyloides stercoralis and hookworm distribution, risk profiling, and control in Cambodia. 2017, Doctoral Thesis, University of Basel, Faculty of Science.

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Official URL: http://edoc.unibas.ch/diss/DissB_12961

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Abstract

Soil-transmitted helminths (STH) disproportionally affect the poorest and thrive in warm areas where sanitation conditions are poor.
Infection with the threadworm, Strongyloides stercoralis, is among the most neglected tropical diseases and extremely common in Cambodia. A national control strategy for this parasite has not yet been defined.
The aim of this PhD study was to contribute to the knowledge-base that will guide S. stercoralis control efforts in Cambodia, by documenting post-treatment reinfection risk and morbidity associated with infection, and by estimating the national prevalence of the parasite and assessing its geographical distribution across the country. Secondary objectives included profiling hookworm infection risk in the region, either alone or in concurrence with S. stercoralis.
The study found that about one third of the Cambodian population was infected with S. stercoralis.
Importantly, we found that chemotherapy-based control of S. stercoralis using ivermectin was feasible and highly beneficial, and its impact was enhanced by improved sanitation.
Treatment resolved dermatological and gastrointestinal symptoms in infected patients. The cost of ivermectin in Cambodia currently prevents the roll-out of control programmes.
Ivermectin donation, subsidization, or the production of affordable generics are urgently needed so that control can be implemented without further delay.
Advisors:Tanner, Marcel and Odermatt, Peter and Stothard, Russel
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Malaria Vaccines (Tanner)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Health Interventions > Malaria Vaccines (Tanner)
UniBasel Contributors:Forrer, Armelle and Tanner, Marcel and Odermatt, Peter
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:12961
Thesis status:Complete
Bibsysno:Link to catalogue
Number of Pages:1 Online-Ressource (xx, 306 Seiten)
Language:English
Identification Number:
Last Modified:27 Jul 2019 04:30
Deposited On:01 Apr 2019 14:13

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