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Elevated nitric oxide production mediates beta-amyloid-induced mitochondria failure

Keil, U. and Bonert, A. and Marques, C. A. and Strosznajder, J. B. and Müller-Spahn, F. and Müller, W. E. and Eckert, A.. (2004) Elevated nitric oxide production mediates beta-amyloid-induced mitochondria failure. Polish journal of pharmacology, Vol. 56, no. 5. pp. 631-634.

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Official URL: http://edoc.unibas.ch/dok/A5253474

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Abstract

Mitochondrial dysfunction has been identified in a large proportion of neurodegenerative disorders including Alzheimer's disease (AD). In addition, the involvement of nitric oxide (NO) has been implicated in the pathogenesis of AD. Thus, we investigated the effects of the Swedish double mutation (K670M/N671L) in the beta-amyloid precursor protein (APPsw) on NO levels and mitochondrial function in PC12 cells. Interestingly, APPsw PC12 cells showed increased NO levels, decreased cytochrome C oxidase activity and reduced ATP levels compared to wild-type APP bearing cells and empty vector transfected cells. On the basis of our data, we propose a hypothetical sequence of events linking amyloid beta-peptide and NO production with mitochondria failure.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
UniBasel Contributors:Eckert, Anne
Item Type:Article, refereed
Article Subtype:Book Review
Bibsysno:Link to catalogue
ISSN:1230-6002
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:22 Mar 2012 14:23
Deposited On:22 Mar 2012 13:36

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