edoc

Correlates and outcomes of alcohol use after single solid organ transplantation : a systematic review and meta-analysis

Dobbels, Fabienne and Denhaerynck, Kris and Klem, Mary Lou and Sereika, Susan M. and De Geest, Sabina and De Simone, Paolo and B-Serious consortium, and Berben, Lut and Binet, Isabelle and Burkhalter, Hanna and Drent, Gerda and Duerinckx, Nathalie and Engberg, Sandra J. and Glass, Tracy and Gordon, Elisa and Kirsch, Monika and Kugler, Christiane and Lerret, Stacee and Rossmeissl, Anja and Russell, Cynthia and Schmidt-Trucksäss, Arno and de Almeida, Samira Scalso. (2019) Correlates and outcomes of alcohol use after single solid organ transplantation : a systematic review and meta-analysis. Transplantation reviews, 33 (1). pp. 17-28.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/68456/

Downloads: Statistics Overview

Abstract

Reviews on alcohol use in transplant recipients focus on liver recipients and their risk of post-transplant rejection, but do not assess alcohol use in kidney, heart, or lung transplant recipients. This systematic review and meta-analysis aims to synthesize the evidence on correlates and outcomes of any alcohol use and at-risk drinking after solid organ transplantation (Tx).; We searched 4 databases for quantitative studies in adult heart, liver, kidney and lung Tx recipients, investigating associations between post-Tx alcohol use and correlates and/or clinical, economic or quality of life outcomes. Paper selection, data extraction and quality assessment were performed by 2 reviewers independently. A pooled odds ratio (OR) was computed for each correlate/outcome reported ≥5 times.; Of the 5331 studies identified, 76 were included in this systematic review (93.3% on liver Tx; mean sample size 148.9 (SD = 160.2); 71.9% male; mean age 48.9 years (SD = 6.5); mean time post-Tx 57.7 months (SD = 23.1)). On average, 23.6% of patients studied used alcohol post-transplant. Ninety-three correlates of any post-Tx alcohol use were identified, and 9 of the 19 pooled ORs were significantly associated with a higher odds for any post-Tx alcohol use: male gender, being employed post-transplant, smoking pre-transplant, smoking post-transplant, a history of illicit drug use, having first-degree relatives who have alcohol-related problems, sobriety <6 months prior to transplant, a history of psychiatric illness, and having received treatment for alcohol-related problems pre-transplant. On average 15.1% of patients had at-risk drinking. A pooled OR was calculated for 6 of the 47 correlates of post-Tx at risk drinking investigated, of which pre-transplant smoking was the only correlate being significantly associated with this behavior. None of the outcomes investigated were significantly associated with any use or at-risk drinking.; Correlates of alcohol use remain under-investigated in solid organ transplant recipients other than liver transplantation. Further research is needed to determine whether any alcohol use or at-risk drinking is associated with poorer post-transplant outcomes. Our meta-analysis highlights avenues for future research of higher methodological quality and improved clinical care.; PROSPERO protocol CRD42015003333.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Institut für Pflegewissenschaft
03 Faculty of Medicine > Departement Public Health > Institut für Pflegewissenschaft > Pflegewissenschaft (De Geest)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Biostatistics > Biostatistics Frequentist Modelling (Kwiatkowski)
UniBasel Contributors:De Geest, Sabina M. and Glass, Tracy and Schmidt-Trucksäss, Arno and Berben, Lut and Denhaerynck, Kris
Item Type:Article, refereed
Article Subtype:Review Article
Publisher:Elsevier
ISSN:0955-470X
e-ISSN:1557-9816
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:06 Jul 2022 13:43
Deposited On:23 Apr 2019 09:30

Repository Staff Only: item control page