edoc

Protein structure homology modelling using SWISS-MODEL Workspace

Bordoli, L. and Kiefer, F. and Arnold, K. and Benkert, P. and Battey, J. and Schwede, T.. (2009) Protein structure homology modelling using SWISS-MODEL Workspace. Nature Protocols, Vol. 4, H. 1. pp. 1-13.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A5259333

Downloads: Statistics Overview

Abstract

Homology modeling aims to build three-dimensional protein structure models using experimentally determined structures of related family members as templates. SWISS-MODEL workspace is an integrated Web-based modeling expert system. For a given target protein, a library of experimental protein structures is searched to identify suitable templates. On the basis of a sequence alignment between the target protein and the template structure, a three-dimensional model for the target protein is generated. Model quality assessment tools are used to estimate the reliability of the resulting models. Homology modeling is currently the most accurate computational method to generate reliable structural models and is routinely used in many biological applications. Typically, the computational effort for a modeling project is less than 2 h. However, this does not include the time required for visualization and interpretation of the model, which may vary depending on personal experience working with protein structures.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Bioinformatics (Schwede)
UniBasel Contributors:Schwede, Torsten
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publishing Group
ISSN:1754-2189
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:03 Sep 2015 08:58
Deposited On:22 Mar 2012 13:34

Repository Staff Only: item control page