Waterhouse, Andrew and Bertoni, Martino and Bienert, Stefan and Studer, Gabriel and Tauriello, Gerardo and Gumienny, Rafal and Heer, Florian T. and de Beer, Tjaart A. P. and Rempfer, Christine and Bordoli, Lorenza and Lepore, Rosalba and Schwede, Torsten. (2018) SWISS-MODEL: homology modelling of protein structures and complexes. Nucleic acids research, 46 (W1). W296-W303.
Full text not available from this repository.
Official URL: https://edoc.unibas.ch/64205/
Downloads: Statistics Overview
Abstract
Homology modelling has matured into an important technique in structural biology, significantly contributing to narrowing the gap between known protein sequences and experimentally determined structures. Fully automated workflows and servers simplify and streamline the homology modelling process, also allowing users without a specific computational expertise to generate reliable protein models and have easy access to modelling results, their visualization and interpretation. Here, we present an update to the SWISS-MODEL server, which pioneered the field of automated modelling 25 years ago and been continuously further developed. Recently, its functionality has been extended to the modelling of homo- and heteromeric complexes. Starting from the amino acid sequences of the interacting proteins, both the stoichiometry and the overall structure of the complex are inferred by homology modelling. Other major improvements include the implementation of a new modelling engine, ProMod3 and the introduction a new local model quality estimation method, QMEANDisCo. SWISS-MODEL is freely available at https://swissmodel.expasy.org.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Bioinformatics (Schwede) |
|---|---|
| UniBasel Contributors: | Schwede, Torsten and Waterhouse, Andrew Mark and Bertoni, Martino and Bienert, Stefan and Studer, Gabriel and Tauriello, Gerardo and Gumienny, Rafal Wojciech and Heer, Florian and de Beer, Tjaart and Bordoli, Lorenza and Lepore, Rosalba |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| ISSN: | 1362-4962 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
|
| Last Modified: | 27 Apr 2020 10:42 |
| Deposited On: | 27 Apr 2020 10:42 |
Repository Staff Only: item control page