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The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications

Philippsen, P. and Kleine, K. and Pohlmann, R. and Dusterhoft, A. and Hamberg, K. and Hegemann, J. H. and Obermaier, B. and Urrestarazu, L. A. and Aert, R. and Albermann, K. and Altmann, R. and Andre, B. and Baladron, V. and Ballesta, J. P. and Becam, A. M. and Beinhauer, J. and Boskovic, J. and Buitrago, M. J. and Bussereau, F. and Coster, F. and Crouzet, M. and D'Angelo, M. and Dal Pero, F. and De Antoni, A. and Hani, J.. (1997) The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications. Nature, Vol. 387, no. 6632, Suppl.. pp. 93-98.

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Official URL: http://edoc.unibas.ch/dok/A5257612

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Abstract

In 1992 we started assembling an ordered library of cosmid clones from chromosome XIV of the yeast Saccharomyces cerevisiae. At that time, only 49 genes were known to be located on this chromosome and we estimated that 80% to 90% of its genes were yet to be discovered. In 1993, a team of 20 European laboratories began the systematic sequence analysis of chromosome XIV. The completed and intensively checked final sequence of 784,328 base pairs was released in April, 1996. Substantial parts had been published before or had previously been made available on request. The sequence contained 419 known or presumptive protein-coding genes, including two pseudogenes and three retrotransposons, 14 tRNA genes, and three small nuclear RNA genes. For 116 (30%) protein-coding sequences, one or more structural homologues were identified elsewhere in the yeast genome. Half of them belong to duplicated groups of 6-14 loosely linked genes, in most cases with conserved gene order and orientation (relaxed interchromosomal synteny). We have considered the possible evolutionary origins of this unexpected feature of yeast genome organization.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Applied Microbiology (Philippsen)
05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Research IT (Podvinec)
UniBasel Contributors:Philippsen, Peter and Pöhlmann, Rainer
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Macmillan
ISSN:0028-0836
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Jun 2012 06:44
Deposited On:22 Mar 2012 13:34

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