Kaufmann, Beat A. and Goetschalckx, Kaatje and Min, Son Y. and Maeder, Micha T. and Bucher, Urs and Nietlispach, Fabian and Bernheim, Alain M. and Pfisterer, Matthias E. and Brunner-La Rocca, Hans-Peter and Time-Chf investigators, . (2015) Improvement in left ventricular ejection fraction and reverse remodeling in elderly heart failure patients on intense NT-proBNP-guided therapy. International Journal of Cardiology, 191. pp. 286-293.
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Official URL: https://edoc.unibas.ch/62161/
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Abstract
BACKGROUND: In chronic heart failure, left ventricular ejection fraction (LVEF) is considered to be stable. Intensified therapy may improve survival, but little is known whether this is associated with reverse remodeling and dependent on age and NT-proBNP guidance. We aimed to define the evolution of LVEF under intensified therapy in relation to age and NT-proBNP guidance. METHODS AND RESULTS: Echocardiography was performed at baseline, 12 and 18months in TIME-CHF, a trial comparing NT-proBNP versus symptom-guided therapy in patients aged 60 to 74 and </=75 years. LVEF, LV end diastolic volume index (LVEDVI) and end systolic volume index (LVESVI) were assessed. LVEF increased from 31.3 +/- 10.7% to 39.1+/-11.8% at 18 months (p /=75 years. TRIAL REGISTRATION: http://isrctn.org Identifier: ISRCTN43596477.
| Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Cardiovascular Molecular Imaging (Kaufmann) |
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| UniBasel Contributors: | Kaufmann, Beat |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| ISSN: | 1874-1754 (Electronic) 0167-5273 (Linking) |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
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| Last Modified: | 10 Nov 2018 13:19 |
| Deposited On: | 10 Nov 2018 13:19 |
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