Anti-plasmodial flavonoid from Pistacia atlantica

Adams, M. and Plitzko, I. and Kaiser, M. and Brun, R. and Hamburger, M.. (2009) Anti-plasmodial flavonoid from Pistacia atlantica. Phytochemistry Letters, Vol. 2. pp. 159-162.

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Official URL: http://edoc.unibas.ch/dok/A5250913

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In the course of a medium throughput screen of 640 plant extracts for antimalarial activity an ethyl acetate extract of Pistacia atlantica DC. (Anacardiaceae) was found to be active. With analytical scale time-based HPLC separation and testing for antiplasmodial activity in combination with hyphenated methods (HPLC-PDA, -MSn, HR-MS, off line microprobe NMR) the active substance was identified. Subsequent isolation and structure elucidation yielded flavone 3-methoxycarpachromene. It had an IC50 of 3.4 μM towards Plasmodium falciparum K1 strain
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Ehemalige Einheiten Pharmazie > Pharmazeutische Biologie (Hamburger)
UniBasel Contributors:Hamburger, Matthias
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:23
Deposited On:22 Mar 2012 13:33

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