Meier-Abt, Fabienne and Bentires-Alj, Mohamed. (2014) How pregnancy at early age protects against breast cancer. Trends in Molecular Medicine, 20 (3). pp. 143-153.
Full text not available from this repository.
Official URL: https://edoc.unibas.ch/61373/
Downloads: Statistics Overview
Abstract
Pregnancy at an early age has a strong protective effect against breast cancer in humans and rodents. Postulated mechanisms underlying this phenomenon include alterations in the relative dynamics of hormone and growth factor-initiated cell fate-determining signaling pathways within the hierarchically organized mammary gland epithelium. Recent studies in epithelial cell subpopulations isolated from mouse and human mammary glands have shown that early pregnancy decreases the proportion of hormone receptor-positive cells and causes pronounced changes in gene expression as well as decreased proliferation in stem/progenitor cells. The changes include downregulation of Wnt and transforming growth factor beta (TGFbeta) signaling. These new findings highlight the importance of cell-cell interactions within the mammary gland epithelium in modulating cancer risk and provide potential targets for breast cancer prevention strategies.
| Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Tumor Heterogeneity Metastasis and Resistance (Bentires-Alj) |
|---|---|
| UniBasel Contributors: | Bentires-Alj, Mohamed |
| Item Type: | Article, refereed |
| Article Subtype: | Further Journal Contribution |
| Publisher: | Elsevier |
| ISSN: | 1471-4914 |
| e-ISSN: | 1471-499X |
| Note: | Publication type according to Uni Basel Research Database: Journal item |
| Identification Number: |
|
| Last Modified: | 16 Jul 2020 15:00 |
| Deposited On: | 16 Jul 2020 15:00 |
Repository Staff Only: item control page