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The Type III Secretion System

Sorg, I. and Cornelis, G. R.. (2009) The Type III Secretion System. In: Bacterial secreted proteins. Norfolk, pp. 93-116.

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Official URL: http://edoc.unibas.ch/dok/A5259106

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Abstract

The type-III secretion system (T3SS) is an export machine used by pathogenic Gram-negative bacteria to deliver proteins straight into the eukaryotic cytosol with the aim to subvert the host cell defense. After the discovery of T3S in 1990, significant progress has been made in the understanding of its structure, assembly and function. The basic structure consisting of the membrane-embedded basal body, the needle and the tip structure has been analyzed in more details. In the last years, the structure of several structural components has been solved and important insights into the assembly process have been gained. Furthermore, comparing the T3SS of pathogenic bacteria with the flagellum the relationship between these two structures becomes obvious. Besides the structural similarities, the assembly of these two nanomachines shows some commonalities like for example the length control of external structures like the T3 needle and the flagellar hook. In addition to the export machine the complete T3SS also includes the pore forming translocator proteins, effector proteins and a set of specific chaperones. Here, we review different aspects of the T3SS focusing on the structure and assembly of this fascinating nanomachine.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Molecular Microbiology (Cornelis)
UniBasel Contributors:Cornelis, Guy R.
Item Type:Book Section, refereed
Book Section Subtype:Further Contribution in a Book
Bibsysno:Link to catalogue
Publisher:Caister Academic Press
ISBN:978-1-904455-42-4
Note:Publication type according to Uni Basel Research Database: Book item
Last Modified:22 Mar 2012 14:23
Deposited On:22 Mar 2012 13:32

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