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In vivo catalyzed new-to-nature reactions

Rebelein, Johannes G. and Ward, Thomas R.. (2018) In vivo catalyzed new-to-nature reactions. Current Opinion in Biotechnology, 53. pp. 106-114.

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Official URL: http://edoc.unibas.ch/58967/

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Abstract

Bioorthogonal chemistry largely relies on the use of abiotic metals to catalyze new-to-nature reactions in living systems. Over the past decade, metal complexes and metal-encapsulated systems such as nanoparticles have been developed to unravel the reactivity of transition metals, including ruthenium, palladium, iridium, copper, iron, and gold in biological systems. Thanks to these remarkable achievements, abiotic catalysts are able to fluorescently label cells, uncage or form cytotoxic drugs and activate enzymes in cellulo/vivo. Recently, strategies for the delivery of such catalysts to specific cell types, cell compartments or proteins were established. These studies reveal the enormous potential of this emerging field and its application in both medicinal chemistry and in synthetic biology.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward)
UniBasel Contributors:Ward, Thomas R. R. and Rebelein, Johannes Georg
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0958-1669
e-ISSN:1879-0429
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:17 Jul 2019 11:34
Deposited On:22 Jan 2018 13:08

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