Supramolecular Enzyme Mimics

Artificial metalloenzymes result from the incorporation of an organometallic moiety within a macromolecule. In this article, we review the field of artificial metalloenzymes. These are classified according to the host that accommodates the organometallic cofactor: cyclodextrins (“Cyclodextrin-Based Artificial Enzymes” section), ligands bearing a substrate recognition motif (“Artificial Enzymes With Ligands Bearing Substrate Recognition Motifs” section), supramolecular cages (“Cage Molecules as Artificial Enzymes” section), nucleic acids (“DNA-Based Artificial Metalloenzymes” section), and proteins (“Protein-Based Artificial Enzymes” section). Both dative and supramolecular anchoring strategies are reviewed.