Convergent Evolution of Ergothioneine Biosynthesis in Cyanobacteria

Liao, Cangsong and Seebeck, Florian P.. (2017) Convergent Evolution of Ergothioneine Biosynthesis in Cyanobacteria. ChemBioChem, 18 (21). pp. 2115-2118.

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Official URL: http://edoc.unibas.ch/58306/

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Biosynthesis of N-α-trimethyl-2-thiohistidine (ergothioneine) is a frequent trait in cyanobacteria. This sulfur compound may provide essential relief from oxidative stress related to oxygenic photosynthesis. The central steps in ergothioneine biosynthesis are catalyzed by a histidine methyltransferase and an iron-dependent sulfoxide synthase. In this report, we present evidence that some cyanobacteria recruited and adapted a sulfoxide synthase from a different biosynthetic pathway to make ergothioneine. The discovery of a second origin of ergothioneine production underscores the physiological importance of this metabolite and highlights the evolutionary malleability of the thiohistidine biosynthetic machinery.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Molecular Bionics (Seebeck)
UniBasel Contributors:Seebeck, Florian Peter
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:05 Jan 2018 13:38
Deposited On:05 Jan 2018 13:38

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