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Oxytocin and Autism Spectrum Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Ooi, Yoon Phaik and Weng, Shih-Jen and Kossowsky, Joe and Gerger, Heike and Sung, Min. (2017) Oxytocin and Autism Spectrum Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Pharmacopsychiatry, 50 (1). pp. 5-13.

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Official URL: http://edoc.unibas.ch/58277/

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Abstract

Aim: Oxytocin presents an exciting potential to target the core symptoms of autism spectrum disorder (ASD) pharmacologically in an easily administered, cost-effective form with possibly minimal adverse effects. But, there are still major gaps in this area of research. This paper reviewed randomized controlled trials (RCTs) examining the effects of oxytocin administration on social cognition and restricted, repetitive behaviors in individuals with an ASD. Method: Electronic literature searches were conducted from PsycINFO, PubMed, Web of Knowledge, and EMBASE for RCTs published through June 2015. Results: 12 RCTs were included in this review. 7 out of the 11 studies that examined social cognition reported improvements. Additionally, one out of the 4 studies on restricted, repetitive behaviors, reported improvements following oxytocin administration. However, results from our meta-analyses suggest that oxytocin has no significant effect on these 2 domains. Conclusion: Previous evidence revealed mixed findings about the effects of oxytocin on ASD. Given the limited number of RCTs, our summary of findings on the effectiveness of oxytocin on ASD should still be considered tentative.© Georg Thieme Verlag KG Stuttgart · New York.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Klinische Psychologie und Psychotherapie (Gaab)
UniBasel Contributors:Ooi, Yoon Phaik and Kossowsky, Joe and Gerger, Heike
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Thieme
ISSN:0720-4280
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:13 Aug 2018 15:36
Deposited On:13 Aug 2018 15:36

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