Jenny, A. and Minvielle-Sebastia, L. and Preker, P. J. and Keller, W.. (1996) Sequence similarity between the 73-kilodalton protein of mammalian CPSF and a subunit of yeast polyadenylation factor I. Science, 274 (5292). pp. 1514-1517.
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Official URL: http://edoc.unibas.ch/dok/A5257974
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Abstract
The 3' ends of most eukaryotic messenger RNAs are generated by endonucleolytic cleavage and polyadenylation. In mammals, the cleavage and polyadenylation specificity factor (CPSF) plays a central role in both steps of the processing reaction. Here, the cloning of the 73-kilodalton subunit of CPSF is reported. Sequence analyses revealed that a yeast protein (Ysh1) was highly similar to the 73-kD polypeptide. Ysh1 constitutes a new subunit of polyadenylation factor I (PFI), which has a role in yeast pre-mRNA 3'-end formation. This finding was unexpected because in contrast to CPSF, PFI is only required for the polyadenylation reaction. These results contribute to the understanding of how 3'-end processing factors may have evolved.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Cell Biology (Keller) |
|---|---|
| UniBasel Contributors: | Keller, Walter |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | American Association for the Advancement of Science |
| ISSN: | 0036-8075 |
| e-ISSN: | 1095-9203 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 07 Nov 2017 15:37 |
| Deposited On: | 22 Mar 2012 13:31 |
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