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Antioxidant Functionalized Polymer Capsules to Prevent Oxidative Stress

Larrañaga, Aitor and Mohd Isa, Isma Liza and Patil, Vaibhav and Thamboo, Sagana and Lomora, Mihai and Fernández-Yague, Marc A. and Sarasua, Jose-Ramon and Palivan, Cornelia G. and Pandit, Abhay. (2018) Antioxidant Functionalized Polymer Capsules to Prevent Oxidative Stress. Acta Biomaterialia, 67. pp. 21-31.

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Official URL: http://edoc.unibas.ch/57900/

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Abstract

Polymeric capsules exhibit significant potential for therapeutic applications as microreactors, where the bio-chemical reactions of interest are efficiently performed in a spatial and time defined manner due to the encapsulation of an active biomolecule (e.g., enzyme) and control over the transfer of reagents and products through the capsular membrane. In this work, catalase loaded polymer capsules functionalized with an external layer of tannic acid (TA) are fabricated via a layer-by-layer approach using calcium carbonate as a sacrificial template. The capsules functionalised with TA exhibit a higher scavenging capacity for hydrogen peroxide and hydroxyl radicals, suggesting that the external layer of TA shows intrinsic antioxidant properties, and represents a valid strategy to increase the overall antioxidant potential of the developed capsules. Additionally, the hydrogen peroxide scavenging capacity of the capsules is enhanced in the presence of the encapsulated catalase. The capsules prevent oxidative stress in an in vitro inflammation model of degenerative disc disease. Moreover, the expression of matrix metalloproteinase-3 (MMP-3), and disintegrin and metalloproteinase with thrombospondin motif-5 (ADAMTS-5), which represents the major proteolytic enzymes in intervertebral disc, are attenuated in the presence of the polymer capsules. This platform technology exhibits potential to reduce oxidative stress, a key modulator in the pathology of a broad range of inflammatory diseases.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
05 Faculty of Science > Departement Chemie > Chemie > Physikalische Chemie (Palivan)
UniBasel Contributors:Palivan, Cornelia G
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:1742-7061
e-ISSN:1878-7568
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:13 Jun 2018 09:04
Deposited On:20 Dec 2017 08:53

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