Berger, C. and Greiff, V. and John, S. and Koenig, K. and Bigler, M. and Recher, M. and Hess, C. and Daikeler, T.. (2015) Risk factors for pneumocystis pneumonia in giant cell arteritis: a single-centre cohort study. Clinical and Experimental Rheumatology, 33 (2, Suppl 89). pp. 122-125.
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Official URL: http://edoc.unibas.ch/57793/
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Abstract
OBJECTIVES: Pneumocystis jiroveci pneumonia (PCP) is a life-threatening opportunistic infection. Few PCP cases in giant cell arteritis (GCA) have been described, but it remains unknown, which patients need PCP prophylaxis.
METHODS: Sixty-two patients with GCA from a prospective cohort were studied to identify treatment-related predictors of PCP infection.
RESULTS: Four PCP infections occurred, all in patients treated with methotrexate in addition to prednisone. Moreover, PCP is associated with higher cumulative PDN doses and severe lymphocytopenia (<400/μl).
CONCLUSIONS: Our findings support PCP-prophylaxis in GCA patients who are treated with methotrexate and PDN, and need high prednisone doses to achieve remission, or develop severe lymphocytopenia.
METHODS: Sixty-two patients with GCA from a prospective cohort were studied to identify treatment-related predictors of PCP infection.
RESULTS: Four PCP infections occurred, all in patients treated with methotrexate in addition to prednisone. Moreover, PCP is associated with higher cumulative PDN doses and severe lymphocytopenia (<400/μl).
CONCLUSIONS: Our findings support PCP-prophylaxis in GCA patients who are treated with methotrexate and PDN, and need high prednisone doses to achieve remission, or develop severe lymphocytopenia.
| Faculties and Departments: | 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Allgemeine innere Medizin USB > Ambulante innere Medizin (Hess C) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Allgemeine innere Medizin USB > Ambulante innere Medizin (Hess C) 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Rheumatologie > Rheumatologie (Kyburz) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Rheumatologie > Rheumatologie (Kyburz) 03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Immunobiology (Hess C) 03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Immunodeficiency (Recher) 03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Translational Immunology (Berger) |
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| UniBasel Contributors: | Berger, Christoph T. and Hess, Christoph and Recher, Mike |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Clinical and Experimental Rheumatology |
| ISSN: | 0392-856x |
| e-ISSN: | 1593-098X |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 08 Oct 2018 17:53 |
| Deposited On: | 08 Oct 2018 17:53 |
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