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The nature and evolution of genomic diversity in the Mycobacterium tuberculosis complex

Brites, Daniela and Gagneux, Sebastien. (2017) The nature and evolution of genomic diversity in the Mycobacterium tuberculosis complex. Advances in experimental medicine and biology, 1019. pp. 1-26.

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Official URL: http://edoc.unibas.ch/57729/

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Abstract

The Mycobacterium tuberculosis Complex (MTBC) consists of a clonal group of several mycobacterial lineages pathogenic to a range of different mammalian hosts. In this chapter, we discuss the origins and the evolutionary forces shaping the genomic diversity of the human-adapted MTBC. Advances in whole-genome sequencing have brought invaluable insights into the macro-evolution of the MTBC, and the biogeographical distribution of the different MTBC lineages, the phylogenetic relationships between these lineages. Moreover, micro-evolutionary processes start to be better understood, including those influencing bacterial mutation rates and those governing the fate of new mutations emerging within patients during treatment. Current genomic and epidemiological evidence reflect the fact that, through ecological specialization, the MTBC affecting humans became an obligate and extremely well-adapted human pathogen. Identifying the adaptive traits of human-adapted MTBC and unraveling the bacterial loci that interact with human genomic variation might help identify new targets for developing better vaccines and designing more effective treatments.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Tuberculosis Research (Gagneux)
UniBasel Contributors:Brites, Daniela and Gagneux, Sebastien
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Springer
ISSN:0065-2598
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:21 Dec 2017 14:40
Deposited On:21 Dec 2017 14:40

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