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Ferrocene derivatives of liquid chiral molecules allow assignment of absolute configuration by X-ray crystallography

Holstein, Philipp M. and Holstein, Julian J. and Escudero-Adan, Eduardo C. and Baudoin, Olivier and Echavarren, Antonio M.. (2017) Ferrocene derivatives of liquid chiral molecules allow assignment of absolute configuration by X-ray crystallography. Tetrahedron: Asymmetry, 28 (10). pp. 1321-1329.

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Abstract

The present study investigates a synthetically simple ferrocene derivatization of natural products and active pharmaceutical ingredients. Seven new crystal structures are analyzed together with 16 structures of ferrocene derivatives reported previously. In all cases, the unambiguous determination of the absolute structure was established from anomalous dispersion using the methods of Flack and Parsons. A comparison with other derivatization approaches shows the advantage of the described ferrocene derivatization for establishing the absolute configuration of novel compounds.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Synthetische Chemie (Baudoin)
UniBasel Contributors:Baudoin, Olivier
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0957-4166
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:17 Aug 2018 12:19
Deposited On:20 Dec 2017 08:46

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