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Strain diversity and the evolution of antibiotic resistance

Borrell, Sonia and Trauner, Andrej. (2017) Strain diversity and the evolution of antibiotic resistance. Advances in experimental medicine and biology, 1019. pp. 263-279.

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Official URL: http://edoc.unibas.ch/57511/

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Abstract

Drug resistance is best thought of as an ongoing biological process. Resistant bacteria must emerge, become established and ultimately transmit in order to be relevant to human health. In this context, genetic diversity can influence the rate and likelihood of resistance emerging; it can also modulate the net physiological impact of resistance and the propensity of an organism to improve any defects that arise from it. Combined, these effects can have an impact on a larger scale, with highly transmissible drug-resistant bacterial strains posing a formidable threat to global health. These considerations are pertinent to the future of tuberculosis control as well. In this chapter, we review our current understanding of the impact of genetic diversity in the broadest sense on the evolution of drug-resistant members of the Mycobacterium tuberculosis complex.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Tuberculosis Research (Gagneux)
UniBasel Contributors:Borrell Farnov, Sonia and Trauner, Andrej
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Springer
ISSN:0065-2598
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:21 Dec 2017 12:48
Deposited On:21 Dec 2017 12:48

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