Placebo: misunderstandings and prejudices

Breidert, Matthias and Hofbauer, Karl. (2009) Placebo: misunderstandings and prejudices. Deutsches Ärzteblatt international, Vol. 106, H. 46. pp. 751-755.

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Official URL: http://edoc.unibas.ch/dok/A5258604

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Background: The role of placebos is often misunderstood, leading both to overvaluation and to inappropriate disdain. The effect of a placebo that contains no pharmacologically active substance is often confused with the effect of administration by a physician. The aim of this article is to review the current data on placebos, evaluate these data critically, and provide a well-founded and understandable explanation of the effects that placebos do and do not possess. Methods: Selective literature review. Results: Recent studies employing modern imaging techniques have provided objective correlates of the effect of placebo administration for certain indications. A recent paper even suggested a genetic basis for it. Two main mechanisms underlie the effect of placebo administration: conditioned reflexes, which are subconscious, and the patient's expectations, which are conscious. Further factors include the physician's personality and the setting in which the treatment takes place. Conclusions: The mechanisms of action of placebo administration, with which positive therapeutic effects can be achieved with little effort, should be consciously exploited by physicians when giving their patients pharmacologically active medications as well.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Hofbauer)
03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Angewandte Pharmakologie (Hofbauer)
UniBasel Contributors:Hofbauer, Karl G.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Deutscher Ärzte-Verlag
Note:Variant title: Placebo : Missverständnisse und Vorurteile -- Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Mar 2013 11:10
Deposited On:22 Mar 2012 13:31

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