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The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles

Mueller, C. A. and Broz, P. and Muller, S. A. and Ringler, P. and Erne-Brand, F. and Sorg, I. and Kuhn, M. and Engel, A. and Cornelis, G. R.. (2005) The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles. Science, Vol. 310, H. 5748. pp. 674-676.

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Official URL: http://edoc.unibas.ch/dok/A5259142

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Abstract

Many pathogenic bacteria use injectisomes to deliver effector proteins into host cells through type III secretion. Injectisomes consist of a basal body embedded in the bacterial membranes and a needle. In Yersinia, translocation of effectors requires the YopB and YopD proteins, which form a pore in the target cell membrane, and the LcrV protein, which assists the assembly of the pore. Here we report that LcrV forms a distinct structure at the tip of the needle, the tip complex. This unique localization of LcrV may explain its crucial role in the translocation process and its efficacy as the main protective antigen against plague.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Engel)
05 Faculty of Science > Departement Biozentrum > Infection Biology
05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Molecular Microbiology (Cornelis)
UniBasel Contributors:Broz, Petr and Engel, Andreas H and Cornelis, Guy R.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Association for the Advancement of Science
ISSN:0036-8075
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Feb 2013 08:44
Deposited On:22 Mar 2012 13:31

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