Adenovirus-specific IgG maturation as a surrogate marker in acute exacerbations of COPD

Boeck, Lucas and Gencay, Mikael and Roth, Michael and Hirsch, Hans H. and Christ-Crain, Mirjam and Mueller, Beat and Tamm, Michael and Stolz, Daiana. (2014) Adenovirus-specific IgG maturation as a surrogate marker in acute exacerbations of COPD. Chest, 146 (2). pp. 339-347.

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Official URL: http://edoc.unibas.ch/55857/

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B cells in airways and lung parenchyma may be involved in COPD evolution; however, whether their pathogenic role is beneficial or harmful remains controversial. The objective of this study was to investigate the maturation of adenovirus-specific immunoglobulins in patients with COPD with respect to clinical outcome.; The presence of adenovirus-specific immunoglobulins during acute exacerbation of COPD (AECOPD) was analyzed at exacerbation and 2 to 3 weeks later. Patients with detectable adenovirus-specific IgM and low IgG avidity were grouped into fast and delayed IgG maturation. The clinical outcome of both groups was evaluated.; Of 208 patients, 43 (20.7%) had serologic evidence of recent adenovirus infection and were grouped by fast IgG maturation (26 patients) and delayed IgG maturation (17 patients). Baseline characteristics, AECOPD therapy, and duration of hospitalization were similar in both groups, but the AECOPD recurrence rate within 6 months was higher (P = .003), and there was a trend for earlier AECOPD-related rehospitalizations (P = .061) in the delayed IgG maturation group. The time to rehospitalization or death within 2 years was shorter in patients with delayed IgG maturation (P = .003). Adenovirus-specific IgG maturation was an independent predictor of the number of AECOPD recurrences within 6 months (P = .001) and the occurrence of hospitalization or death within 2 years (P = .005).; Delayed immunoglobulin avidity maturation following COPD exacerbation is associated with worse outcomes.; ISRCTN Register; No.: ISRCTN77261143; URL: www.isrctn.org.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Pneumologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Pneumologie
UniBasel Contributors:Boeck, Lucas and Müller, Beat
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Dec 2017 08:11
Deposited On:05 Oct 2017 06:25

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