A coronin 1-dependent decision switch in juvenile mice determines population of the peripheral naïve T cell compartment

Lang, Mathias and Mori, Mayumi and Ruer-Laventie, Julie and Pieters, Jean. (2017) A coronin 1-dependent decision switch in juvenile mice determines population of the peripheral naïve T cell compartment. Journal of Immunology, 199 (7). pp. 2421-2431.

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Following thymic maturation, T cells egress as recent thymic emigrants to peripheral lymphoid organs where they undergo an additional maturation step to mature naive T cells that circulate through secondary lymphoid organs ready to be activated upon pathogenic challenges. Thymic maturation and peripheral T cell survival depend on several signaling cascades, but whether a dedicated mechanism exists that exclusively regulates homeostasis of mature naive T cells without affecting thymocytes and/or recent thymic emigrants remains unknown. In this article, we provide evidence for a specific and exclusive role of the WD repeat containing protein coronin 1 in the maintenance of naive T cells in peripheral lymphoid organs. We show that coronin 1 is dispensable for thymocyte survival and development, egress from the thymus, and survival of recent thymic emigrants. Importantly, coronin 1–deficient mice possessed comparable levels of peripheral T cells within the first 2 wk after birth but failed to populate the peripheral T cell compartment at later stages. Furthermore, dendritic cell– and IL-2/7–dependent T cell survival was found to be independent of coronin 1. Together, these results suggest the existence of a hitherto unrecognized coronin 1–dependent decision switch early during life that is responsible for peripheral naive T cell survival and homeostasis.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Biochemistry (Pieters)
UniBasel Contributors:Pieters, Jean
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association of Immunologists
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:25 Oct 2017 09:52
Deposited On:25 Oct 2017 09:52

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