Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5

Floto, R. A. and MacAry, P. A. and Boname, J. M. and Mien, T. S. and Kampmann, B. and Hair, J. R. and Huey, O. S. and Houben, E. N. G. and Pieters, J. and Day, C. and Oehlmann, W. and Singh, M. and Smith, K. G. C. and Lehner, P. J.. (2006) Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5. Science, 314 (5798). pp. 454-458.

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An effective host immune response to mycobacterial infection must control pathogen dissemination without inducing immunopathology. Constitutive overexpression of mycobacterial heat shock protein (myHsp70) is associated with impaired bacterial persistence, but the immune-mediated mechanisms are unknown. We found that myHsp70, in addition to enhancing antigen delivery to human dendritic cells, signaled through the CCR5 chemokine receptor, promoting dendritic cell aggregation, immune synapse formation between dendritic cells and T cells, and the generation of effector immune responses. Thus, CCR5 acts as a pattern-recognition receptor for myHsp70, which may have implications for both the pathophysiology of tuberculosis and the use of myHsps in tumor-directed immunotherapy.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Biochemistry (Pieters)
UniBasel Contributors:Pieters, Jean
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association for the Advancement of Science
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:13 Sep 2018 15:28
Deposited On:22 Mar 2012 13:30

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