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Iridium-Catalyzed Asymmetric Hydrogenation of Olefins with Chiral N,P and C,N Ligands

Woodmansee, David H. and Pfaltz, Andreas. (2011) Iridium-Catalyzed Asymmetric Hydrogenation of Olefins with Chiral N,P and C,N Ligands. In: Iridium Catalysis. Berlin, pp. 31-76.

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Abstract

Asymmetric hydrogenation is one of the most important catalytic methods for the preparation of optically active compounds. For a long time, chiral rhodium- and ruthenium–diphosphine complexes were the catalysts of choice in this field. However, their application range in the asymmetric hydrogenation of olefins is limited to substrates bearing a coordinating group adjacent to the C=C bond. These limitations were surmounted with the advent of iridium complexes with chiral N,P-ligands. For a wide range of unfunctionalized olefins, excellent enantioselectivities can now be achieved with low catalyst loadings. Moreover, these catalysts also allow highly enantioselective hydrogenation of various functionalized olefins, heterocycles such as furans or indoles, and imines. Research in this field is productive with new catalysts giving high enantioselectivities for difficult substrates appearing at an ever more frequent rate. These methods greatly expand the repertoire of reactions available to synthetic chemists for the preparation of optically active compounds in a reliable and an atom-economical fashion.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Synthetische organische Chemie (Pfaltz)
UniBasel Contributors:Pfaltz, Andreas
Item Type:Book Section
Book Section Subtype:Further Contribution in a Book
Publisher:Springer
ISBN:978-3-642-15333-4
e-ISBN:978-3-642-15334-1
Series Name:Topics in Organometallic Chemistry
Issue Number:34
Note:Publication type according to Uni Basel Research Database: Book item
Identification Number:
Last Modified:13 Apr 2018 06:17
Deposited On:12 Apr 2017 10:10

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