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Common Kibra alleles are associated with human memory performance

Papassotiropoulos, Andreas and Stephan, Dietrich A. and Huentelman, Matthew J. and Hoerndli, Frederic J. and Craig, David W. and Pearson, John V. and Huynh, Kim-Dung and Brunner, Fabienne and Corneveaux, Jason and Osborne, David and Wollmer, M. Axel and Aerni, Amanda and Coluccia, Daniel and Hänggi, Jürgen and Mondadori, Christian R. A. and Buchmann, Andreas and Reiman, Eric M. and Caselli, Richard J. and Henke, Katharina and de Quervain, Dominique J.-F.. (2006) Common Kibra alleles are associated with human memory performance. Science, 314 (5798). pp. 475-478.

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Official URL: http://edoc.unibas.ch/dok/A5257161

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Abstract

Human memory is a polygenic trait. We performed a genome-wide screen to identify memory-related gene variants. A genomic locus encoding the brain protein KIBRA was significantly associated with memory performance in three independent, cognitively normal cohorts from Switzerland and the United States. Gene expression studies showed that KIBRA was expressed in memory-related brain structures. Functional magnetic resonance imaging detected KIBRA allele-dependent differences in hippocampal activations during memory retrieval. Evidence from these experiments suggests a role for KIBRA in human memory.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
UniBasel Contributors:Papassotiropoulos, Andreas and de Quervain, Dominique J.-F.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Association for the Advancement of Science
ISSN:0036-8075
e-ISSN:1095-9203
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:27 Nov 2017 10:40
Deposited On:22 Mar 2012 13:30

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