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The NCAM1 gene set is linked to depressive symptoms and their brain structural correlates in healthy individuals

Petrovska, Jana and Coynel, David and Fastenrath, Matthias and Milnik, Annette and Auschra, Bianca and Egli, Tobias and Gschwind, Leo and Hartmann, Francina and Loos, Eva and Sifalakis, Klara and Vogler, Christian and de Quervain, Dominique J.-F. and Papassotiropoulos, Andreas and Heck, Angela. (2017) The NCAM1 gene set is linked to depressive symptoms and their brain structural correlates in healthy individuals. Journal of Psychiatric Research, 91. pp. 116-123.

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Official URL: http://edoc.unibas.ch/54775/

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Abstract

Depressive symptoms exist on a continuum, the far end of which is found in depressive disorders. Utilizing the continuous spectrum of depressive symptoms may therefore contribute to the understanding of the biological underpinnings of depression. Gene set enrichment analysis (GSEA) is an important tool for the identification of gene groups linked to complex traits, and was applied in the present study on genome-wide association study (GWAS) data of depression scores and their brain-level structural correlates in healthy young individuals. On symptom level (i.e. depression scores), robust enrichment was identified for two gene sets: NCAM1 Interactions and Collagen Formation. Depression scores were also associated with decreased fractional anisotropy (FA) - a brain white matter property - within the forceps minor and the left superior temporal longitudinal fasciculus. Within each of these tracts, mean FA value of depression score-associated voxels was used as a phenotype in a subsequent GSEA. The NCAM1 Interactions gene set was significantly enriched in these tracts. By linking the NCAM1 Interactions gene set to depression scores and their structural brain correlates in healthy participants, the current study contributes to the understanding of the molecular underpinnings of depressive symptomatology.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Cognitive Neuroscience (de Quervain)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Kognitive Neurowissenschaften (de Quervain)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Kognitive Neurowissenschaften (de Quervain)
UniBasel Contributors:Papassotiropoulos, Andreas and Coynel, David and Petrovska, Jana and Fastenrath, Matthias and Milnik, Annette and Auschra, Bianca and Egli, Tobias and Gschwind, Leo and Hartmann, Francina R. and Loos, Eva and Sifalakis, Klara and Vogler, Christian and de Quervain, Dominique J.-F. and Heck, Angela
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0022-3956
e-ISSN:1879-1379
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:25 Jun 2018 15:36
Deposited On:04 Jul 2017 13:46

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