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Alpha-1-antichymotrypsin gene polymorphism and risk for sporadic Alzheimer's disease in a German population

Schwab, S. G. and Bagli, M. and Papassotiropoulos, A. and Jessen, F. and Maier, W. and Rao, M. L. and Heun, R.. (1999) Alpha-1-antichymotrypsin gene polymorphism and risk for sporadic Alzheimer's disease in a German population. Dementia and Geriatric Cognitive Disorders, 10 (6). pp. 469-472.

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Official URL: http://edoc.unibas.ch/dok/A5257224

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Abstract

The A allele of a common A-T polymorphism in the signal peptide of alpha(1)-antichymotrypsin gene (ACT) has been reported to contribute a two- to threefold increased risk to Alzheimer's disease (AD) patients who carry the apolipoprotein E epsilon4 (APOE epsilon4) genotype. Since the ACT expression in AD brains is enhanced in particular in areas that develop amyloid plaques, the ACT polymorphism is considered to be a good candidate gene. We have analyzed this polymorphism in 102 AD patients and 191 matched controls, all originating from Western Germany. No statistically significant differences in allele frequencies and in genotype distribution of ACT could be shown between AD patients and controls. When we analyzed the polymorphism in APOE epsilon4 carriers, no overrepresentation in our AD group could be shown for the ACT*AA genotype carriers. Copyrightz1999S.KargerAG,Basel
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
UniBasel Contributors:Papassotiropoulos, Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Karger
ISSN:1420-8008
e-ISSN:1421-9824
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:11 Oct 2017 13:53
Deposited On:22 Mar 2012 13:30

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