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Identification of virus-encoded microRNAs

Pfeffer, S. and Zavolan, M. and Grasser, F. A. and Chien, M. and Russo, J. J. and Ju, J. and John, B. and Enright, A. J. and Marks, D. and Sander, C. and Tuschl, T.. (2004) Identification of virus-encoded microRNAs. Science, Vol. 304, no. 5671. pp. 734-736.

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Official URL: http://edoc.unibas.ch/dok/A5259672

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Abstract

RNA silencing processes are guided by small RNAs that are derived from double-stranded RNA. To probe for function of RNA silencing during infection of human cells by a DNA virus, we recorded the small RNA profile of cells infected by Epstein-Barr virus (EBV). We show that EBV expresses several microRNA (miRNA) genes. Given that miRNAs function in RNA silencing pathways either by targeting messenger RNAs for degradation or by repressing translation, we identified viral regulators of host and/or viral gene expression.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Bioinformatics (Zavolan)
UniBasel Contributors:Zavolan, Mihaela
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Association for the Advancement of Science
ISSN:0036-8075
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:22
Deposited On:22 Mar 2012 13:30

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