Fallet, Bénédict. Differentiation of protective B cell responses in chronic viral infection. 2016, Doctoral Thesis, University of Basel, Faculty of Science.
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Official URL: http://edoc.unibas.ch/diss/DissB_12121
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Abstract
Immune subversion represents a hallmark of persistent infection, but microbial suppression of B cell responses remains mechanistically ill-defined. Adoptive transfer experiments in a chronic viral infection model evidenced the rapid and profound decimation of B cells that responded to virus or to concomitantly administered protein. Decimation affected naïve and memory B cells and resulted from biased differentiation into short-lived antibody-secreting cells. It was driven by type I interferon (IFN-I) signaling to several cell types including dendritic cells, T cells and myeloid cells. Durable B cell responses were restored upon IFN-I receptor blockade or, partially, when depleting myeloid cells or key IFN-I-induced cytokines. B cell decimation represents a molecular mechanism of humoral immune subversion and reflects an unsustainable “all-in” response of B cells in IFN-I-driven inflammation.
Advisors: | Hess, Christoph and Pinschewer, Daniel and Haller, Otto |
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UniBasel Contributors: | Hess, Christoph and Pinschewer, Daniel |
Item Type: | Thesis |
Thesis Subtype: | Doctoral Thesis |
Thesis no: | 12121 |
Thesis status: | Complete |
Number of Pages: | 1 Online-Ressource (85 Seiten) |
Language: | English |
Identification Number: |
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edoc DOI: | |
Last Modified: | 05 Apr 2018 17:35 |
Deposited On: | 18 May 2017 07:34 |
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