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Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75

Carter, B. D. and Kaltschmidt, C. and Kaltschmidt, B. and Offenhauser, N. and Bohm-Matthaei, R. and Baeuerle, P. A. and Barde, Y. A.. (1996) Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75. Science, Vol. 272, no. 5261. pp. 542-545.

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Official URL: http://edoc.unibas.ch/dok/A5259535

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Abstract

Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) selectively bind to distinct members of the Trk family of tyrosine kinase receptors, but all three bind with similar affinities to the neurotrophin receptor p75 (p75NTR). The biological significance of neurotrophin binding to p75NTR in cells that also express Trk receptors has been difficult to ascertain. In the absence of TrkA, NGF binding to p75NGR activated the transcription factor nuclear factor kappa B (NF-kappa B) in rat Schwann cells. This activation was not observed in Schwann cells isolated from mice that lacked p75NTR. The effect was selective for NGF; NF-kappa B was not activated by BDNF or NT-3.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Barde)
UniBasel Contributors:Barde, Yves-Alain
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Association for the Advancement of Science
ISSN:0036-8075
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:22
Deposited On:22 Mar 2012 13:30

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