Protein kinase G from pathogenic mycobacteria promotes survival within macrophages

Walburger, A. and Koul, A. and Ferrari, G. and Nguyen, L. and Prescianotto-Baschong, C. and Huygen, K. and Klebl, B. and Thompson, C. and Bacher, G. and Pieters, J.. (2004) Protein kinase G from pathogenic mycobacteria promotes survival within macrophages. Science, 304 (5678). pp. 1800-1804.

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Pathogenic mycobacteria resist lysosomal delivery after uptake into macrophages, allowing them to survive intracellularly. We found that the eukaryotic-like serine/threonine protein kinase G from pathogenic mycobacteria was secreted within macrophage phagosomes, inhibiting phagosome-lysosome fusion and mediating intracellular survival of mycobacteria. Inactivation of protein kinase G by gene disruption or chemical inhibition resulted in lysosomal localization and mycobacterial cell death in infected macrophages. Besides identifying a target for the control of mycobacterial infections, these findings suggest that pathogenic mycobacteria have evolved eukaryotic-like signal transduction mechanisms capable of modulating host cell trafficking pathways.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Biochemistry (Pieters)
UniBasel Contributors:Pieters, Jean
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association for the Advancement of Science
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:13 Sep 2018 15:23
Deposited On:22 Mar 2012 13:30

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