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The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome

Dietrich, F. S. and Voegeli, S. and Brachat, S. and Lerch, A. and Gates, K. and Steiner, S. and Mohr, C. and Pohlmann, R. and Luedi, P. and Choi, S. and Wing, R. A. and Flavier, A. and Gaffney, T. D. and Philippsen, P.. (2004) The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome. Science, Vol. 304, no. 5668. pp. 304-307.

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Official URL: http://edoc.unibas.ch/dok/A5257596

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Abstract

We have sequenced and annotated the genome of the filamentous ascomycete Ashbya gossypii. With a size of only 9.2 megabases, encoding 4718 protein-coding genes, it is the smallest genome of a free-living eukaryote yet characterized. More than 90% of A. gossypii genes show both homology and a particular pattern of synteny with Saccharomyces cerevisiae. Analysis of this pattern revealed 300 inversions and translocations that have occurred since divergence of these two species. It also provided compelling evidence that the evolution of S. cerevisiae included a whole genome duplication or fusion of two related species and showed, through inferred ancient gene orders, which of the duplicated genes lost one copy and which retained both copies.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Applied Microbiology (Philippsen)
05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Research IT (Podvinec)
UniBasel Contributors:Philippsen, Peter and Pöhlmann, Rainer
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Association for the Advancement of Science
ISSN:0036-8075
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Jun 2012 06:45
Deposited On:22 Mar 2012 13:30

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