Transcription and RNAi in heterochromatic gene silencing

Bühler, Marc and Moazed, Danesh. (2007) Transcription and RNAi in heterochromatic gene silencing. Nature structural & molecular biology, Vol. 14, no. 11. pp. 1041-1048.

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Official URL: http://edoc.unibas.ch/dok/A5251087

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Recent findings have challenged the longstanding belief that heterochromatin is an inert and transcriptionally inactive structure. Studies in organisms ranging from fission yeast to animals have found that noncoding RNAs transcribed from heterochromatic DNA repeats function in the assembly and function of heterochromatin. In this review, we discuss the roles of RNA and RNA turnover in mechanisms that mediate heterochromatin assembly and keep heterochromatic domains silent.
Faculties and Departments:09 Associated Institutions > Friedrich Miescher Institut FMI
UniBasel Contributors:Bühler, Marc
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publ. Group
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:22
Deposited On:22 Mar 2012 13:30

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