Dynamics of force-induced DNA slippage

Neher, Richard A. and Gerland, Ulrich. (2004) Dynamics of force-induced DNA slippage. Physical Review Letters, 93 (19). p. 198102.

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We study the base pairing dynamics of DNA with repetitive sequences where local strand slippage can create, annihilate, and move bulge loops. Using an explicit theoretical model, we find a rich dynamical behavior as a function of an applied shear force f: reptationlike dynamics at f=f(c) with a rupture time tau scaling as N3 with its length N, drift-diffusion dynamics for f(c)<f<f(*), and a dynamical transition to an unraveling mode of strand separation at f=f(*). We predict a viscoelastic behavior for periodic DNA with time and force scales that can be programmed into its sequence.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Computational Modeling of Biological Processes (Neher)
UniBasel Contributors:Neher, Richard
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Physical Society
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Nov 2019 16:21
Deposited On:03 Nov 2017 11:24

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