Kinetic accessibility of buried DNA sites in nucleosomes

Möbius, Wolfram and Neher, Richard A. and Gerland, Ulrich. (2006) Kinetic accessibility of buried DNA sites in nucleosomes. Physical Review Letters, 97 (20). p. 208102.

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Official URL: http://edoc.unibas.ch/54006/

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Using a theoretical model for spontaneous partial DNA unwrapping from histones, we study the transient exposure of protein-binding DNA sites within nucleosomes. We focus on the functional dependence of the rates for site exposure and reburial on the site position, which is measurable experimentally and pertinent to gene regulation. We find the dependence to be roughly described by a random walker model. Close inspection reveals a surprising physical effect of flexibility-assisted barrier crossing, which we characterize within a toy model, the "semiflexible Brownian rotor."
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Computational Modeling of Biological Processes (Neher)
UniBasel Contributors:Neher, Richard
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Physical Society
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:18 Sep 2019 07:24
Deposited On:27 Nov 2017 12:30

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