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Immobilization of an Artificial Imine Reductase within Silica Nanoparticles Improves its Performance

Hestericova, Martina and Correro, M. Rita and Lenz, Markus and Corvini, Philippe F.-X. and Shahgaldian, Patrick and Ward, Thomas R.. (2016) Immobilization of an Artificial Imine Reductase within Silica Nanoparticles Improves its Performance. Chemical Communications , 52. pp. 9462-9465.

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Abstract

Silica nanoparticles equipped with an artificial imine reductase display remarkable activity towards cyclic imine- and NAD + reduction. The method, based on immobilization and protection of streptavidin on silica nanoparticles, shields the biotinylated metal cofactor against deactivation yielding over 46 000 turnovers in pure samples and 4000 turnovers in crude cellular extracts.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward)
UniBasel Contributors:Ribar Hestericov√°, Martina and Corvini, Philippe F.-X. and Shahgaldian, Patrick and Ward, Thomas R. R.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Royal Society of Chemistry
ISSN:1359-7345
e-ISSN:1364-548X
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:01 Feb 2017 11:13
Deposited On:01 Feb 2017 11:13

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