Ward, Thomas R.. (2016) Directed Evolution of Iridium-Substituted Myoglobin Affords Versatile Artificial Metalloenzymes for Enantioselective C−C Bond-Forming Reactions. Angewandte Chemie International Edition, 55 (48). pp. 14909-14911.
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Abstract
Upgrading myoglobin with iridium : A metal-substitution strategy has been used to afford a repurposed myoglobin for challenging cyclopropanation and intramolecular C−H activation reactions. The performance of the iridium-loaded myoglobin (orange sphere) was improved through directed evolution of eight active-site residues (yellow surface).
| Faculties and Departments: | 05 Faculty of Science > Departement Chemie 05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward) |
|---|---|
| UniBasel Contributors: | Ward, Thomas R. R. |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Wiley |
| ISSN: | 1433-7851 |
| e-ISSN: | 1521-3773 |
| Note: | Publication type according to Uni Basel Research Database: Journal article -- The final publication is available at Wiley, see DOI link |
| Language: | English |
| Identification Number: | |
| edoc DOI: | |
| Last Modified: | 17 Aug 2018 12:52 |
| Deposited On: | 01 Feb 2017 11:09 |
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