Superior Rim Stability of the Lens Capsule Following Manual Over Femtosecond Laser Capsulotomy

Reyes Lua, Magaly and Oertle, Philipp and Camenzind, Leon and Goz, Alexandra and Meyer, Carsten H. and Konieczka, Katarzyna and Loparic, Marko and Halfter, Willi and Henrich, Paul Bernhard. (2016) Superior Rim Stability of the Lens Capsule Following Manual Over Femtosecond Laser Capsulotomy. Investigative Ophthalmology & Visual Science, 57 (6). pp. 2839-2849.

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Official URL: http://edoc.unibas.ch/53459/

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Cataract surgery requires the removal of a circular segment of the anterior lens capsule (LC) by manual or femtosecond laser (FL) capsulotomy. Tears in the remaining anterior LC may compromise surgical outcome. We investigated whether biophysical differences in the rim properties of the LC remaining in the patient after manual or FL capsulotomy (FLC) lead to different risks with regard to anterior tear formation.; Lens capsule samples obtained by either continuous curvilinear capsulorhexis (CCC) or FLC were investigated by light microscopy, laser scanning confocal microscopy, and scanning electron microscopy; atomic force microscopy (AFM) was used to test the biomechanical properties of the LC. The mechanical stability of the LC following either of the two capsulotomy techniques was simulated by using finite-element modeling.; Continuous curvilinear capsulorhexis produced wedge-shaped, uniform rims, while FLC resulted in nearly perpendicular, frayed rims with numerous notches. The LC is composed of two sublayers: a stiff epithelial layer that is abundant with laminin and a softer anterior chamber layer that is predominantly made from collagen IV. Computer models show that stress is uniformly distributed over the entire rim after CCC, while focal high stress concentrations are observed in the frayed profiles of LC after FLC, making the latter procedure more prone to anterior tear formation.; Finite-element modeling based on three-dimensional AFM maps indicated that CCC leads to a capsulotomy rim with higher stress resistance, leading to a lower propensity for anterior radial tears than FLC.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Nanobiology Argovia (Lim)
UniBasel Contributors:Oertle, Philipp and Camenzind, Leon and Loparic, Marko and Henrich, Paul Bernhard
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Association for Research in Vision and Ophthalmology
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:25 Oct 2017 13:09
Deposited On:25 Oct 2017 13:09

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