Eradicating lymphatic filariasis

Kastner, Randee J.. Eradicating lymphatic filariasis. 2015, Doctoral Thesis, University of Basel, Faculty of Science.


Official URL: http://edoc.unibas.ch/diss/DissB_11999

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The neglected tropical disease, lymphatic filariasis (LF), is endemic in 73 countries, primarily among impoverished populations. Infection with LF can damage the lymphatic system, causing permanent disability including hydrocele, lymphedema, and elephantiasis. In 1997, LF was named by the World Health Assembly as a potentially eradicable disease, in part because it is preventable through once yearly treatment administered through mass drug administration (MDA) using albendazole with ivermectin or diethylcarbamazine citrate (DEC). This PhD thesis presents evidence-based guidance on the rationale for investing in LF eradication by providing estimates on the duration of MDA necessary and number of treatments needed to reach local elimination for a variety of transmission archetypes, as well as the potential economic and financial investment needed, the potential health impact and cost-effectiveness of eradicating LF, and the potential health systems savings and gains in worker productivity as a result of averted LF-related morbidity. The results show that across all considerations, including: time, treatments, level of investments necessary, health impact, cost-effectiveness, and broader economic benefits, scaling-up MDA coverage to all endemic communities immediately provides the most favorable results. Ultimately, though, the success of eradicating LF will depend on the political engagement and enthusiasm at all levels.  
Advisors:Tanner, Marcel and Tediosi, Fabrizio and Bockarie, Moses
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Malaria Vaccines (Tanner)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Health Interventions > Malaria Vaccines (Tanner)
UniBasel Contributors:Tanner, Marcel and Tediosi, Fabrizio
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:11999
Thesis status:Complete
Number of Pages:1 Online-Ressource (137 Seiten)
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edoc DOI:
Last Modified:22 Jan 2018 15:52
Deposited On:19 Apr 2017 09:12

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