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Microfluidic Breadboard Approach to Capillary Electrophoresis

Koenka, Israel Joel and Sáiz, Jorge and Rempel, Paul and Hauser, Peter C.. (2016) Microfluidic Breadboard Approach to Capillary Electrophoresis. Analytical Chemistry, 88 (7). pp. 3761-3767.

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Official URL: http://edoc.unibas.ch/52175/

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Abstract

A breadboard approach for electrophoretic separations with contactless conductivity detection is presented. This is based on miniature off-the-shelf components such as syringe pumps, valves, and pressure controllers which could be set up in a very compact overall arrangement. It has a high flexibility for different tasks at hand, and the common operations of hydrodynamic injection and capillary flushing are automated. For demonstration of the versatility of the proposition, several very diverse configurations and modes of electrophoresis were successfully implemented, namely, standard capillary zone electrophoresis, pressure assisted zone electrophoresis, the simultaneous separation of cations and anions by dual-capillary zone electrophoresis, the separation of cationic amino acids by isotachophoresis, as well as the separation of small carboxylic acids by gradient elution moving boundary electrophoresis. The system also allows fast separations, as demonstrated by the analysis of six inorganic cations within 35 s. The approach addresses respective limitations of either conventional capillary electrophoresis instruments as well as electrophoretic lab-on-chip devices, while maintaining a performance in terms of detection limits and reproducibility comparable to standard instrumentation.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Analytische Chemie (Hauser)
UniBasel Contributors:Hauser, Peter C. and Koenka, Israel Joel
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
ISSN:0003-2700
e-ISSN:1520-6882
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:23 Jan 2017 15:30
Deposited On:23 Jan 2017 15:30

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