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Comparison of metal free polymer-dye conjugation strategies in protic solvents

Gaitzsch, Jens and Delahaye, Maarten and Poma, Alessandro and Du Prez, Filip and Battaglia, Giuseppe. (2016) Comparison of metal free polymer-dye conjugation strategies in protic solvents. Polymer Chemistry, 7 (17). pp. 3046-3055.

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Official URL: http://edoc.unibas.ch/52102/

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Abstract

Polymer-dye conjugations are one of the common examples for polymer modifications. They represent a crucial step for imaging in optical microscopy or for tracing and marking macromolecules. In this work, we present a comparison between quick and efficient conjugation reactions that do not rely on the use of a metal catalyst, which could contaminate the resulting polymer and hinder its use for subsequent biological applications. Moreover, since the conjugation strategy needs to be compatible with the solvent system used to solubilise the polymer, we focussed our attention on assessing these conjugation approaches for their feasibility with a sample polymer that is only soluble in protic solvents. The methods studied include the ring-strain promoted azide-alkyne click reaction, thiol/maleimide conjugation as well as the 1,2,4-triazoline-3,5-dione (TAD) with a diene moiety, one of the latest click chemistries available.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Royal Society of Chemistry
ISSN:1759-9954
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:23 Jan 2017 14:52
Deposited On:23 Jan 2017 14:52

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