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Molecular engineering of polymersome surface topology

Ruiz-Perez, Lorena and Messager, Lea and Gaitzsch, Jens and Joseph, Adrian and Sutto, Ludovico and Gervasio, Francesco Luigi and Battaglia, Giuseppe. (2016) Molecular engineering of polymersome surface topology. Science Advances, 2 (4). e1500948.

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Abstract

Biological systems exploit self-assembly to create complex structures whose arrangements are finely controlled from the molecular to mesoscopic level. We report an example of using fully synthetic systems that mimic two levels of self-assembly. We show the formation of vesicles using amphiphilic copolymers whose chemical nature is chosen to control both membrane formation and membrane-confined interactions. We report polymersomes with patterns that emerge by engineering interfacial tension within the polymersome surface. This allows the formation of domains whose topology is tailored by chemical synthesis, paving the avenue to complex supramolecular designs functionally similar to those found in viruses and trafficking vesicles.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association for the Advancement of Science
e-ISSN:2375-2548
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:18 Jan 2017 15:44
Deposited On:18 Jan 2017 15:44

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