Holstein, Philipp M. and Dailler, David and Vantourout, Julien and Shaya, Janah and Millet, Anthony and Baudoin, Olivier. (2016) Synthesis of Strained γ-Lactams by Palladium(0)-Catalyzed C(sp3)−H Alkenylation and Application to Alkaloid Synthesis. Angewandte Chemie, 128 (8). pp. 2855-2859.
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Abstract
A variety of strained α-alkylidene-γ-lactams were synthesized by palladium(0)-catalyzed intramolecular C(sp3)−H alkenylation from easily accessible acyclic and monocyclic bromoalkene precursors. These lactams are valuable intermediates for accessing various classes of mono- and bicylic alkaloids containing a pyrrolidine ring, as illustrated with the synthesis of an advanced model of the marine natural product plakoridine A and of the indolizidine alkaloid δ-coniceine.
| Faculties and Departments: | 05 Faculty of Science 05 Faculty of Science > Departement Chemie 05 Faculty of Science > Departement Chemie > Chemie > Synthetische Chemie (Baudoin) |
|---|---|
| UniBasel Contributors: | Baudoin, Olivier and Dailler, David |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Wiley |
| ISSN: | 0044-8249 |
| e-ISSN: | 1521-3757 |
| Note: | Publication type according to Uni Basel Research Database: Journal article -- The final publication is available at Wiley, see DOI link |
| Language: | English |
| Identification Number: | |
| edoc DOI: | |
| Last Modified: | 17 Aug 2018 11:49 |
| Deposited On: | 09 Jan 2017 15:31 |
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