Autoaggressive behavior is closely related to serotonin availability in schizoaffective disorder

Rao, M. L. and Bräunig, P. and Papassotiropoulos, A.. (1994) Autoaggressive behavior is closely related to serotonin availability in schizoaffective disorder. Pharmacopsychiatry, Vol. 27, H. 5. pp. 202-206.

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Official URL: http://edoc.unibas.ch/dok/A5257240

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Lowered serotonin turnover has been observed in impulsive hetero- and auto-aggressive behavior. Most notably the CSF 5-hydroxyindole acetic acid concentrations were decreased. However, data on CSF or blood serotonin are far from clear-cut, since similar levels in suicidal and non-suicidal patients have also been noted. Longitudinal studies of suicidal patients have revealed pronounced shifts in blood serotonin levels, whereas healthy subjects' blood serotonin levels remained stable. We investigated blood serotonin levels of female schizoaffective patients and healthy women to test whether the fluctuations correlated with changes in autoaggressive behavior. The patients were divided into three groups: nonsuicidal, acutely suicidal, and postsuicidal. Nonsuicidal and postsuicidal schizoaffective patients' and healthy women's blood serotonin levels were similar. Suicidal patients' blood serotonin levels were significantly lower than those of healthy subjects and postsuicidal patients. We interpret the serotonin augmentation after a suicide attempt as a psychobiological correlate of increased neurotransmitter function.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Molecular Neuroscience (Papassotiropoulos)
UniBasel Contributors:Papassotiropoulos, Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:22
Deposited On:22 Mar 2012 13:29

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