Doetsch, Fiona. (2003) A niche for adult neural stem cells. Current Opinion in Genetics & Development, 13 (5). pp. 543-550.
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Official URL: http://edoc.unibas.ch/50352/
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Abstract
The adult mammalian brain harbors multipotent stem cells, which reside and participate in specialized niches that support self-renewal and differentiation. The first cellular and molecular elements of the stem cell niche in the adult brain have been identified and include cell-cell interactions and somatic cell signaling, the vasculature, the extracellular matrix and basal lamina. Furthermore, regulation at the epigenetic level via chromatin modification and remodeling is an integral aspect of stem cell biology. Understanding the in vivo stem cell niche will provide a framework for the elucidation of stem cell function in the adult brain.
Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Neurobiology > Stem Cell Biology (Doetsch) |
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UniBasel Contributors: | Doetsch, Fiona |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Elsevier |
ISSN: | 0959-437X |
e-ISSN: | 1879-0380 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Identification Number: |
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Last Modified: | 23 Nov 2017 10:04 |
Deposited On: | 23 Nov 2017 10:04 |
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