Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts

Oprea, Mihaela and Perelson, A. S.. (1997) Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts. Journal of Immunology, 158 (11). pp. 5155-5162.

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Although most mutations are deleterious, an interplay between somatic mutation and selection within germinal centers (GC) results in rapid generation of high affinity memory B cells. How high affinity B cells with large numbers of mutations are generated and preserved within GC containing at their peak only a few thousand cells has been puzzling. We have developed a model of somatic mutation and B cell expansion within a GC that resolves this puzzle. We show that the frequent recycling of Ag-selected centrocytes back into centroblasts can lead to efficient affinity maturation. Memory cells are generated in large numbers even when most of the selected centrocytes recycle back into centroblasts. Our model suggests that a germinal center reaction in which the output of cells is low up to the point of GC dissociation, followed by the release of centrocytes into the periphery, is advantageous for generating high affinity memory.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Bioinformatics (Zavolan)
UniBasel Contributors:Zavolan, Mihaela
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association of Immunologists
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Nov 2017 10:29
Deposited On:10 Nov 2017 10:29

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