Expression of receptor tyrosine phosphatases during development of the retinotectal projection of the chick

Ledig, M. M. and McKinnell, I. W. and Mrsic-Flogel, T. and Wang, J. and Alvares, C. and Mason, I. and Bixby, J. L. and Mueller, B. K. and Stoker, A. W.. (1999) Expression of receptor tyrosine phosphatases during development of the retinotectal projection of the chick. Journal of Neurobiology, 39 (1). pp. 81-96.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/49660/

Downloads: Statistics Overview


Receptor tyrosine kinases and receptor protein tyrosine phosphatases (RPTPs) appear to coordinate many aspects of neural development, including axon growth and guidance. Here, we focus on the possible roles of RPTPs in the developing avian retinotectal system. Using both in situ hybridization analysis and immunohistochemistry, we show for the first time that five RPTP genes--CRYPalpha, CRYP-2, PTPmu, PTPgamma, and PTPalpha--have different but overlapping expression patterns throughout the retina and the tectum. PTPalpha is restricted to Muller glia cells and radial glia of the tectum, indicating a possible function in controlling neuronal migration. PTPgamma expression is restricted to amacrine neurons. CRYPalpha and CRYP-2 mRNAs in contrast are expressed throughout the retinal ganglion cell layer from where axons grow out to their tectal targets. PTPmu is expressed in a subset of these ganglion cells. CRYPalpha, CRYP-2, and PTPmu proteins are also localized in growth cones of retinal ganglion cell axons and are present in defined laminae of the tectum. Thus, the spatial and temporal expression of three distinct RPTP subtypes--CRYPalpha, CRYP-2, and PTPmu--are consistent with the possibility of their involvement in axon growth and guidance of the retinotectal projection.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Neural Networks (Mrsic-Flogel)
UniBasel Contributors:Mrsic-Flogel, Thomas
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:26 Oct 2017 13:02
Deposited On:26 Oct 2017 13:02

Repository Staff Only: item control page