Prior experience enhances plasticity in adult visual cortex

Hofer, Sonja B. and Mrsic-Flogel, Thomas D. and Bonhoeffer, Tobias and Hübener, Mark. (2006) Prior experience enhances plasticity in adult visual cortex. Nature Neuroscience, 9 (1). pp. 127-132.

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The brain has a remarkable capacity to adapt to alterations in its sensory environment, which is normally much more pronounced in juvenile animals. Here we show that in adult mice, the ability to adapt to changes can be improved profoundly if the mouse has already experienced a similar change in its sensory environment earlier in life. Using the standard model for sensory plasticity in mouse visual cortex-ocular dominance (OD) plasticity-we found that a transient shift in OD, induced by monocular deprivation (MD) earlier in life, renders the adult visual cortex highly susceptible to subsequent MD many weeks later. Irrespective of whether the first MD was experienced during the critical period (around postnatal day 28) or in adulthood, OD shifts induced by a second MD were faster, more persistent and specific to repeated deprivation of the same eye. The capacity for plasticity in the mammalian cortex can therefore be conditioned by past experience.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Neuronal circuits and brain function (Hofer)
UniBasel Contributors:Hofer, Sonja and Mrsic-Flogel, Thomas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature America
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Nov 2017 12:41
Deposited On:27 Nov 2017 12:41

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